Preclinical in vivo animal models of intervertebral disc degeneration. Part 1: A systematic review.

ABSTRACT: Intervertebral disc degeneration (IVDD), a widely recognized cause of lower back pain, is the leading cause of disability worldwide. A myriad of preclinical in vivo animal models of IVDD have been described in the literature. There is a need for critical evaluation of these models to better inform researchers and clinicians to optimize study design and ultimately, enhance experimental outcomes. The purpose of this study was to conduct an extensive systematic literature review to report the variability of animal species, IVDD induction method, and experimental timepoints and endpoints used in in vivo IVDD preclinical research. A systematic literature review of peer-reviewed manuscripts featured on PubMed and EMBASE databases was conducted in accordance with PRISMA guidelines. Studies were i

SUBMITTER: Poletto DL 

PROVIDER: S-EPMC10041387 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature