Sexual Dimorphism in Lesion Size and Sensorimotor Responses Following Spinal Cord Injury.

ABSTRACT: Spinal cord injury (SCI) is a devastating disorder, which impacts the lives of millions of people worldwide with no clinically standardized treatment. Both pro-recovery and anti-recovery factors contribute to the overall outcome after the initial SCI. Sex is emerging as an important variable, which can affect recovery post-SCI. Contusion SCI at T10 was generated in male and female rats. Open-field Basso, Beattie, Bresnahan (BBB) behavioral test, Von Frey test, and CatWalk gate analysis were performed. Histological analysis was performed at the 45-day post-SCI end point. Male/female differences in sensorimotor function recovery, lesion size, and the recruitment of immune cells to the lesion area were measured. A group of males with less severe injuries was included to compare the outcomes f

SUBMITTER: Osimanjiang W 

PROVIDER: S-EPMC10041393 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature