Increased Effective Connectivity of the Left Parietal Lobe During Walking Tasks in Parkinson's Disease.

ABSTRACT:

Background

In Parkinson's disease (PD), walking may depend on the activation of the cerebral cortex. Understanding the patterns of interaction between cortical regions during walking tasks is of great importance.

Objective

This study investigated differences in the effective connectivity (EC) of the cerebral cortex during walking tasks in individuals with PD and healthy controls.

Methods

We evaluated 30 individuals with PD (62.4±7.2 years) and 22 age-matched healthy controls (61.0±6.4 years). A mobile functional near-infrared spectroscopy (fNIRS) was used to record cerebral oxygenation signals in the left prefrontal cortex (LPFC), right prefrontal cortex (RPFC), left parietal lobe (LPL), and right parietal lobe (RPL) and analyze the EC of the cerebral cortex. A wirele

SUBMITTER: Wang Y 

PROVIDER: S-EPMC10041419 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature