Lifelong Cognitive Reserve, Imaging Markers of Brain Aging, and Cognitive Function in Dementia-Free Rural Older Adults: A Population-Based Study.

ABSTRACT:

Background

Cognitive reserve (CR) partly explains cognitive variability in the presence of pathological brain aging.

Objective

We investigated the interplay of lifelong CR with age, sex, and brain aging markers in cognitive phenotypes among older adults with very limited education.

Methods

This population-based cross-sectional study included 179 dementia-free participants (age ≥65 years; 39.7% women; 67.0% had no or elementary education) examined in 2014-2016. We assessed lacunes and volumes of hippocampus, ventricles, grey matter, white matter (WM), and white matter hyperintensities. Lifelong CR score was generated from six lifespan intellectual factors (e.g., education and social support). We used Mini-Mental State Examination (MMSE) score to assess cognition and Pe

SUBMITTER: Li Y 

PROVIDER: S-EPMC10041437 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature