Brain injury biomarkers do not predict delirium in acutely ill older patients: a prospective cohort study.

ABSTRACT: Delirium is a common, serious, and often preventable neuropsychiatric emergency mostly characterized by a disturbance in attention and awareness. Systemic insult and inflammation causing blood-brain-barrier (BBB) damage and glial and neuronal activation leading to more inflammation and cell death is the most accepted theory behind delirium's pathophysiology. This study aims to evaluate the relationship between brain injury biomarkers on admission and delirium in acutely ill older patients. We performed a prospective cohort study which analyzed plasma S100B levels at admission in elderly patients. Our primary outcome was delirium diagnosis. Secondary outcomes were association between S100B, NSE and Tau protein and delirium diagnosis and patients' outcomes (admissions to intensive care, leng

SUBMITTER: de Alencar JCG 

PROVIDER: S-EPMC10041516 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature