Investigating TSPO levels in occupation-related posttraumatic stress disorder.

ABSTRACT: Microglia are immune brain cells implicated in stress-related mental illnesses including posttraumatic stress disorder (PTSD). Their role in the pathophysiology of PTSD, and on neurobiological systems that regulate stress, is not completely understood. We tested the hypothesis that microglia activation, in fronto-limbic brain regions involved in PTSD, would be elevated in participants with occupation-related PTSD. We also explored the relationship between cortisol and microglia activation. Twenty participants with PTSD and 23 healthy controls (HC) completed positron emission tomography (PET) scanning of the 18-kDa translocator protein (TSPO), a putative biomarker of microglia activation using the probe [¹⁸F]FEPPA, and blood samples for measurement of cortisol. [¹⁸F]FE

SUBMITTER: Watling SE 

PROVIDER: S-EPMC10041517 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature