First-in-human clinical trial of the NKT cell-stimulatory glycolipid OCH in multiple sclerosis.

ABSTRACT:

Background

Multiple sclerosis (MS) is an autoimmune inflammatory disease of the central nervous system that causes the damage to the myelin sheath as well as axonal degeneration. Individuals with MS appear to have changes in the numbers and functions of T-cell subsets, leading to an immunological imbalance accompanied by enhanced autoreactivity. In previous preclinical studies, (2 S,3 S,4R)-1-O-(α-D-Galactopyranosyl)-N-tetracosanoyl-2-amino-1,3,4-nonanetriol (OCH), a synthetic analog of α-galactosylceramide stimulatory for invariant NKT (iNKT) cells, has shown therapeutic or disease-preventive immunoregulatory effects in autoimmune disease models such as experimental autoimmune encephalomyelitis (EAE).

Objectives

This study is the first-in-human study of oral OCH to evaluate

SUBMITTER: Sato W 

PROVIDER: S-EPMC10041592 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature