Periderm Fate during Palatogenesis: TGF-β and Periderm Dedifferentiation.

ABSTRACT: Failure of palatogenesis results in cleft palate, one of the most common congenital disabilities in humans. During the final phases of palatogenesis, the protective function of the peridermal cell layer must be eliminated for the medial edge epithelia to adhere properly, which is a prerequisite for the successful fusion of the secondary palate. However, a deeper understanding of the role and fate of the periderm in palatal adherence and fusion has been hampered due to a lack of appropriate periderm-specific genetic tools to examine this cell type in vivo. Here we used the cytokeratin-6A (Krt-6a) locus to develop both constitutive (Krt6ai-Cre) and inducible (Krt6ai-Cre^ERT2) periderm-specific Cre driver mouse lines. These novel lines allowed us to achieve both

SUBMITTER: Saroya G 

PROVIDER: S-EPMC10041600 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature