QCM-D Investigations on Cholesterol-DNA Tethering of Liposomes to Microbubbles for Therapy.

ABSTRACT: Lipid-shelled microbubbles (MBs) offer potential as theranostic agents, capable of providing both contrast enhancement in ultrasound imaging as well as a route for triggered drug release and improved localized drug delivery. A common motif in the design of such therapeutic vehicles is the attachment of the drug carrier, often in the form of liposomes, to the microbubble. Traditionally, such attachments have been based around biotin-streptavidin and maleimide-PDP chemistries. Comparatively, the use of DNA-lipid tethers offers potential advantage. First, their specificity permits the construction of more complex architectures that might include bespoke combinations of different drug-loaded liposomes and/or targeting groups, such as affimers or antibodies. Second, the use of dual-lipid tether

SUBMITTER: Armistead FJ 

PROVIDER: S-EPMC10041634 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature