Metabolic programming of distinct cancer stem cells promotes metastasis of pancreatic ductal adenocarcinoma.

ABSTRACT: Pancreatic ductal adenocarcinoma (PDAC) metastasizes to distant organs, which is the primary cause of mortality; however, specific features mediating organ-specific metastasis remain unexplored. Emerging evidence demonstrates that cancer stem cells (CSCs) and cellular metabolism play a pivotal role in metastasis. Here we investigated the role of distinct subtypes of pancreatic CSCs and their metabolomic signatures in organ-specific metastatic colonization. We found that PDAC consists of ALDH+/CD133+ and drug-resistant (MDR1+) subtypes of CSCs with specific metabolic and stemness signatures. Human PDAC tissues with gemcitabine treatment, autochthonous mouse tumors from Kras^G12D; Pdx1-Cre (KC) and Kras^G12D; Trp53^R172H; Pdx-1 Cre (KPC) mice, and KPC- Liver/Lun

SUBMITTER: Nimmakayala RK 

PROVIDER: S-EPMC10041665 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature