Possible sex difference in latent tuberculosis infection risk among close tuberculosis contacts.

ABSTRACT:

Objectives

More men than women develop and die of tuberculosis (TB). Fewer data exist on sex differences in latent TB infection (LTBI). We assessed for potential sex differences in LTBI acquisition among close TB contacts.

Methods

Regional Prospective Observational Research for TB-Brazil is an observational multi-center cohort of individuals with culture-confirmed pulmonary TB and their close contacts. Participants were enrolled from five sites in Brazil from June 2015 - June 2019. Close contacts were followed for 24 months after enrollment, with LTBI defined as a positive interferon-γ release assay (IGRA; QuantiFERON 3^rd or 4^th generation) at baseline or 6 months. We performed univariate, bivariate, and multivariable logistic regression and propensity-

SUBMITTER: Wada PY 

PROVIDER: S-EPMC10041676 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature