TERRA G-quadruplex stabilization as a new therapeutic strategy for multiple myeloma.

ABSTRACT:

Background

Multiple myeloma (MM) is a hematologic malignancy characterized by high genomic instability, and telomere dysfunction is an important cause of acquired genomic alterations. Telomeric repeat-containing RNA (TERRA) transcripts are long non-coding RNAs involved in telomere stability through the interaction with shelterin complex. Dysregulation of TERRAs has been reported across several cancer types. We recently identified a small molecule, hit 17, which stabilizes the secondary structure of TERRA. In this study, we investigated in vitro and in vivo anti-MM activities of hit 17.

Methods

Anti-proliferative activity of hit 17 was evaluated in different MM cell lines by cell proliferation assay, and the apoptotic process was analyzed by flow cytometry. Gene and protein e

SUBMITTER: Scionti F 

PROVIDER: S-EPMC10041726 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature