Systematic pan-cancer analysis identifies SLC31A1 as a biomarker in multiple tumor types.

ABSTRACT:

Background

Solute Carrier Family 31 Member 1 (SLC31A1) has recently been identified as a cuproptosis-regulatory gene. Recent studies have indicated that SLC31A1 may play a role in colorectal and lung cancer tumorigenesis. However, the role of SLC31A1 and its cuproptosis-regulatory functions in multiple tumor types remains to be further elucidated.

Methods

Online websites and datasets such as HPA, TIMER2, GEPIA, OncoVar, and cProSite were used to extract data on SLC31A1 in multiple cancers. DAVID and BioGRID were used to conduct functional analysis and construct the protein-protein interaction (PPI) network, respectively. The protein expression data of SLC31A1 was obtained from the cProSite database.

Results

The Cancer Genome Atlas (TCGA) datasets showed increased SLC3

SUBMITTER: Kong FS 

PROVIDER: S-EPMC10041742 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature