Identification and validation of tumor-infiltrating lymphocyte-related prognosis signature for predicting prognosis and immunotherapeutic response in bladder cancer.

ABSTRACT:

Background

It has been discovered that tumor-infiltrating lymphocytes (TILs) are essential for the emergence of bladder cancer (BCa). This study aimed to research TIL-related genes (TILRGs) and create a gene model to predict BCa patients' overall survival.

Methods

The RNA sequencing and clinical data were downloaded from the TGCA and GEO databases. Using Pearson correlation analysis, TILRGs were evaluated. Moreover, hub TILRGs were chosen using a comprehensive analysis. By dividing the TCGA-BCa patients into different clusters based on hub TILRGs, we were able to explore the immune landscape between different clusters.

Results

Here, we constructed a model with five hub TILRGs and split all of the patients into two groups, each of which had a different prognosis and cl

SUBMITTER: Li C 

PROVIDER: S-EPMC10041757 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature