The genetic liability to rheumatoid arthritis may decrease hepatocellular carcinoma risk in East Asian population: a Mendelian randomization study.

ABSTRACT:

Background

Patients with rheumatoid arthritis (RA) have a rising possibility of acquiring certain kinds of cancers than the general public. The causal risk association between RA and hepatocellular carcinoma (HCC) remains unknown.

Methods

Genetic summary data from genome-wide association study (GWAS), including RA (n = 19,190) and HCC (n = 197,611), was analyzed. The inverse-variance weighted (IVW) approach was used as the principal analysis, complemented with weighted median, weighted mode, simple median method, and MR-Egger analyses. The genetic data of RA (n = 212,453) was used to verify the results in eastern Asia populations.

Results

The results from the IVW methods indicated that genetically predicted RA was significantly linked with a declined possibility of HC

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC10041783 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature