The predictive value of the modified AFP model for liver transplantation outcomes in multinodular hepatocellular carcinoma patients.

ABSTRACT:

Background

There is a lack of studies focusing on the benefit of liver transplantation (LT) in hepatocellular carcinoma (HCC) patients with > 3 tumors. This study aims to establish a model to effectively predict overall survival in Chinese HCC patients with multiple tumors (> 3 tumors) who undergo LT.

Methods

This retrospective study included 434 HCC liver transplant recipients from the China Liver Transplant Registry. All HCC patients had more than 3 tumor nodules. Three selection criteria systems (i.e., AFP, Metroticket 2.0, and Up-to-7) were compared regarding the prediction of HCC recurrence. The modified AFP model was established by univariate and multivariate competing risk analyses.

Results

The AFP score 2 and the AFP score ≥ 3 groups had 5-year recurrence rate

SUBMITTER: Wang J 

PROVIDER: S-EPMC10041809 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature