Simple prediction of COVID-19 convalescent plasma units with high levels of neutralization antibodies.

ABSTRACT:

Background

Hyperimmune convalescent COVID-19 plasma (CCP) containing anti-SARS-CoV-2 neutralizing antibodies (NAbs) was proposed as a therapeutic option for patients early in the new coronavirus disease pandemic. The efficacy of this therapy depends on the quantity of neutralizing antibodies (NAbs) in the CCP units, with titers ≥ 1:160 being recommended. The standard neutralizing tests (NTs) used for determining appropriate CCP donors are technically demanding and expensive and take several days. We explored whether they could be replaced by high-throughput serology tests and a set of available clinical data.

Methods

Our study included 1302 CCP donors after PCR-confirmed COVID-19 infection. To predict donors with high NAb titers, we built four (4) multiple logistic regressio

SUBMITTER: Jazbec K 

PROVIDER: S-EPMC10042109 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature