Baseline gene expression in subcutaneous adipose tissue predicts diet-induced weight loss in individuals with obesity.

ABSTRACT:

Background

Weight loss effectively reduces cardiometabolic health risks among people with overweight and obesity, but inter-individual variability in weight loss maintenance is large. Here we studied whether baseline gene expression in subcutaneous adipose tissue predicts diet-induced weight loss success.

Methods

Within the 8-month multicenter dietary intervention study DiOGenes, we classified a low weight-losers (low-WL) group and a high-WL group based on median weight loss percentage (9.9%) from 281 individuals. Using RNA sequencing, we identified the significantly differentially expressed genes between high-WL and low-WL at baseline and their enriched pathways. We used this information together with support vector machines with linear kernel to build classifier models tha

SUBMITTER: Oghabian A 

PROVIDER: S-EPMC10042157 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature