Point-A vs. volume-based brachytherapy for the treatment of cervix cancer: A meta-analysis.

ABSTRACT:

Background & purpose

To report disease-free survival (DFS) for volume-based and point-A based brachytherapy (BT) in locally advanced cervical cancer.

Materials & methods

We conducted a meta-analysis of studies assessing the effects of point-A and volume-based brachytherapy on 3-year DFS. Studies including stage I-IVA cervical cancer patients were included if standard treatment of concomitant chemo-radiotherapy and high-dose- or pulsed dose rate BT was delivered. The primary outcome was 3-year DFS, and secondary outcomes were 3-year local control (LC), 3-year overall survival (OS) and late toxicity. A random-effects subgroup meta-analysis was done.

Results

In total, 5499 studies were screened, of which 24 studies with 5488 patients were eligible. There was significant

SUBMITTER: Hande V 

PROVIDER: S-EPMC10042219 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature