New Insights on DR and DQ Human Leukocyte Antigens in Anti-LGI1 Encephalitis.

ABSTRACT:

Background and objectives

To explore the clinical characteristics and HLA associations of patients with anti-leucine-rich glioma-inactivated 1 encephalitis (LGI1E) from a large single center in Israel. Anti-LGI1E is the most commonly diagnosed antibody-associated encephalitic syndrome in adults. Recent studies of various populations reveal significant associations with specific HLA genes. We examined the clinical characteristics and HLA associations of a cohort of Israeli patients.

Methods

Seventeen consecutive patients with anti-LGI1E diagnosed at Tel Aviv Medical Center between the years 2011 and 2018 were included. HLA typing was performed using next-generation sequencing at the tissue typing laboratory of Sheba Medical Center and compared with data from the Ezer Mizion B

SUBMITTER: Segal Y 

PROVIDER: S-EPMC10042442 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature