Mass Transport Model of Radiation Response: Calibration and Application to Chemoradiation for Pancreatic Cancer.

ABSTRACT:

Purpose

The benefit of radiation therapy for pancreatic ductal adenocarcinoma (PDAC) remains unclear. We hypothesized that a new mechanistic mathematical model of chemotherapy and radiation response could predict clinical outcomes a priori, using a previously described baseline measurement of perfusion from computed tomography scans, normalized area under the enhancement curve (nAUC).

Methods and materials

We simplified an existing mass transport model that predicted cancer cell death by replacing previously unknown variables with averaged direct measurements from randomly selected pathologic sections of untreated PDAC. This allowed using nAUC as the sole model input to approximate tumor perfusion. We then compared the predicted cancer cell death to the actual cell death mea

SUBMITTER: Wang CX 

PROVIDER: S-EPMC10042520 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature