GABA facilitates spike propagation through branch points of sensory axons in the spinal cord.

ABSTRACT: Movement and posture depend on sensory feedback that is regulated by specialized GABAergic neurons (GAD2⁺) that form axo-axonic contacts onto myelinated proprioceptive sensory axons and are thought to be inhibitory. However, we report here that activating GAD2⁺ neurons directly with optogenetics or indirectly by cutaneous stimulation actually facilitates sensory feedback to motor neurons in rodents and humans. GABA_A receptors located at or near nodes of Ranvier of sensory axons cause this facilitation by preventing spike propagation failure at the many axon branch points, which is otherwise common without GABA. In contrast, GABA_A receptors are generally lacking from axon terminals and so cannot inhibit transmitter release onto motor neurons, unli

SUBMITTER: Hari K 

PROVIDER: S-EPMC10042549 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature