High expression of TARS is associated with poor prognosis of endometrial cancer.

ABSTRACT:

Introduction

Endometrial cancer is the second largest and most common cancer in the world. It is urgent to explore novel biomarkers.

Methods

Data were obtained from The Cancer Genome Atlas (TCGA) database. The receiver operating characteristic (ROC) curves, Kaplan-Meier curves and Cox analysis, nomograms, gene set enrichment analysis (GSEA) were conducted. Cell proliferation experiments were performed in Ishikawa cell.

Results

TARS was significantly highly expressed in serous type, G3 grade, and deceased status. Significant association was between high TARS expression with poor overall survival (P = 0.0012) and poor disease specific survival (P = 0.0034). Significant differences were observed in advanced stage, G3 and G4, and old. The stage, diabetes, hi

SUBMITTER: Si L 

PROVIDER: S-EPMC10042687 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature