Dual-signal readout paper-based wearable biosensor with a 3D origami structure for multiplexed analyte detection in sweat.

ABSTRACT: In this research, we design and implement a small, convenient, and noninvasive paper-based microfluidic sweat sensor that can simultaneously detect multiple key biomarkers in human sweat. The origami structure of the chip includes colorimetric and electrochemical sensing regions. Different colorimetric sensing regions are modified with specific chromogenic reagents to selectively identify glucose, lactate, uric acid, and magnesium ions in sweat, as well as the pH value. The regions of electrochemical sensing detect cortisol in sweat by molecular imprinting. The entire chip is composed of hydrophilically and hydrophobically treated filter paper, and 3D microfluidic channels are constructed by using folding paper. The thread-based channels formed after the hydrophilic and hydrophobic modific

SUBMITTER: Cheng Y 

PROVIDER: S-EPMC10042807 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature