Assessing the structure of the posterior visual pathway in bilateral macular degeneration.

ABSTRACT: Macular degeneration (MD) embodies a collection of disorders causing a progressive loss of central vision. Cross-sectional MRI studies have revealed structural changes in the grey and white matter in the posterior visual pathway in MD but there remains a need to understand how such changes progress over time. To that end we assessed the posterior pathway, characterising the visual cortex and optic radiations over a ~ 2-year period in MD patients and controls. We performed cross-sectional and longitudinal analysis of the former. Reduced cortical thickness and white matter integrity were observed in patients compared to controls, replicating previous findings. While faster, neither the rate of thinning in visual cortex nor the reduction in white matter integrity during the ~ 2-year period re

SUBMITTER: Brown HDH 

PROVIDER: S-EPMC10042846 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature