Genetic risk of depression is different in subgroups of dietary ratio of tryptophan to large neutral amino acids.

ABSTRACT: Manipulation of intake of serotonin precursor tryptophan has been exploited to rapidly induce and alleviate depression symptoms. While studies show that this latter effect is dependent on genetic vulnerability to depression, the effect of habitual tryptophan intake in the context of predisposing genetic factors has not been explored. Our aim was to investigate the effect of habitual tryptophan intake on mood symptoms and to determine the effect of risk variants on depression in those with high and low tryptophan intake in the whole genome and specifically in serotonin and kynurenine pathways. 63,277 individuals in the UK Biobank with data on depressive symptoms and tryptophan intake were included. We compared two subpopulations defined by their habitual diet of a low versus a high ratio of

SUBMITTER: Bruncsics B 

PROVIDER: S-EPMC10042855 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature