Genome-wide association study of population-standardised cognitive performance phenotypes in a rural South African community.

ABSTRACT: Cognitive function is an indicator for global physical and mental health, and cognitive impairment has been associated with poorer life outcomes and earlier mortality. A standard cognition test, adapted to a rural-dwelling African community, and the Oxford Cognition Screen-Plus were used to capture cognitive performance as five continuous traits (total cognition score, verbal episodic memory, executive function, language, and visuospatial ability) for 2,246 adults in this population of South Africans. A novel common variant, rs73485231, reached genome-wide significance for association with episodic memory using data for ~14 million markers imputed from the H3Africa genotyping array data. Window-based replication of previously implicated variants and regions of interest support the discover

SUBMITTER: Soo CC 

PROVIDER: S-EPMC10043003 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature