Activation of TRPV1 receptor facilitates myelin repair following demyelination via the regulation of microglial function.

ABSTRACT: The transient receptor potential vanilloid 1 (TRPV1) is a non-selective cation channel that is activated by capsaicin (CAP), the main component of chili pepper. Despite studies in several neurological diseases, the role of TRPV1 in demyelinating diseases remains unknown. Herein, we reported that TRPV1 expression was increased within the corpus callosum during demyelination in a cuprizone (CPZ)-induced demyelination mouse model. TRPV1 deficiency exacerbated motor coordinative dysfunction and demyelination in CPZ-treated mice, whereas the TRPV1 agonist CAP improved the behavioral performance and facilitated remyelination. TRPV1 was predominantly expressed in Iba1⁺ microglia/macrophages in human brain sections of multiple sclerosis patients and mouse corpus callosum under demyelina

SUBMITTER: Sun JX 

PROVIDER: S-EPMC10043010 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature