Interspecies interaction reduces selection for antibiotic resistance in Escherichia coli.

ABSTRACT: Evolution of microbial traits depends on the interaction of a species with its environment as well as with other coinhabiting species. However, our understanding of the evolution of specific microbial traits, such as antibiotic resistance in complex environments is limited. Here, we determine the role of interspecies interactions on the dynamics of nitrofurantoin (NIT) resistance selection among Escherichia coli. We created a synthetic two-species community comprised of two variants of E. coli (NIT susceptible and resistant) and Bacillus subtilis in minimal media with glucose as the sole carbon source. We show that the presence of B. subtilis significantly slows down the selection for the resistant E. coli mutant when NIT is present and that this slowdown is not due to competition for reso

SUBMITTER: Nair RR 

PROVIDER: S-EPMC10043022 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature