Technical Review of Clinical Outcomes Assessments Across the Continuum of Alzheimer's Disease.

ABSTRACT:

Introduction

Insight into the relationship between concepts that matter to the people affected by Alzheimer's disease (AD) and the clinical outcome assessments (COAs) commonly used in AD clinical studies is limited. Phases 1 and 2 of the What Matters Most (WMM) study series identified and quantitatively confirmed 42 treatment-related outcomes that are important to people affected by AD.

Methods

We compared WMM concepts rated as "very important" or higher to items included in COAs used commonly in AD studies.

Results

Twenty COAs designed to assess signs, symptoms, and impacts across the spectrum of AD were selected for review. Among these 20 COAs, only 5 reflected 12 or more WMM concepts [Integrated Alzheimer's Disease Rating Scale (iADRS), Alzheimer's Disease Cooperat

SUBMITTER: DiBenedetti DB 

PROVIDER: S-EPMC10043075 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature