Arc ubiquitination regulates endoplasmic reticulum-mediated Ca²⁺ release and CaMKII signaling.

ABSTRACT: Synaptic plasticity relies on rapid, yet spatially precise signaling to alter synaptic strength. Arc is a brain enriched protein that is rapidly expressed during learning-related behaviors and is essential for regulating metabotropic glutamate receptor-mediated long-term depression (mGluR-LTD). We previously showed that disrupting the ubiquitination capacity of Arc enhances mGluR-LTD; however, the consequences of Arc ubiquitination on other mGluR-mediated signaling events is poorly characterized. Here we find that pharmacological activation of Group I mGluRs with S-3,5-dihydroxyphenylglycine (DHPG) increases Ca²⁺ release from the endoplasmic reticulum (ER). Disrupting Arc ubiquitination on key amino acid residues enhances DHPG-induced ER-mediated Ca²⁺ release. These a

SUBMITTER: Ghane MA 

PROVIDER: S-EPMC10043188 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature