Implantation with SHED sheet induced with homogenate protein of spinal cord promotes functional recovery from spinal cord injury in rats.

ABSTRACT: Introduction: After spinal cord injury (SCI) occurs, the lesion is in a growth inhibitory microenvironment that severely hinders neural regeneration. In this microenvironment, inhibitory factors are predominant and factors that promote nerve regeneration are few. Improving neurotrophic factors in the microenvironment is the key to treating SCI. Methods: Based on cell sheet technology, we designed a bioactive material with a spinal cord-like structure -SHED sheet induced with homogenate protein of spinal cord (hp-SHED sheet). Hp-SHED sheet was implanted into the spinal cord lesion for treating SCI rats with SHED suspensions as a control to investigate the effects on nerve regeneration. Results: Hp-SHED sheet revealed a highly porous three-dimensional inner structure, wh

SUBMITTER: Mi S 

PROVIDER: S-EPMC10043224 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature