Structure-function relationships in the sodium chloride cotransporter.

ABSTRACT: The thiazide sensitive Na⁺:Cl^- cotransporter (NCC) is the principal via for salt reabsorption in the apical membrane of the distal convoluted tubule (DCT) in mammals and plays a fundamental role in managing blood pressure. The cotransporter is targeted by thiazide diuretics, a highly prescribed medication that is effective in treating arterial hypertension and edema. NCC was the first member of the electroneutral cation-coupled chloride cotransporter family to be identified at a molecular level. It was cloned from the urinary bladder of the Pseudopleuronectes americanus (winter flounder) 30 years ago. The structural topology, kinetic and pharmacology properties of NCC have been extensively studied, determining that the transmembrane domain (TM) coordinat

SUBMITTER: Moreno E 

PROVIDER: S-EPMC10043231 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature