N6-methyladenosine reader YTHDF family in biological processes: Structures, roles, and mechanisms.

ABSTRACT: As the most abundant and conserved internal modification in eukaryote RNAs, N6-methyladenosine (m⁶A) is involved in a wide range of physiological and pathological processes. The YT521-B homology (YTH) domain-containing family proteins (YTHDFs), including YTHDF1, YTHDF2, and YTHDF3, are a class of cytoplasmic m⁶A-binding proteins defined by the vertebrate YTH domain, and exert extensive functions in regulating RNA destiny. Distinct expression patterns of the YTHDF family in specific cell types or developmental stages result in prominent differences in multiple biological processes, such as embryonic development, stem cell fate, fat metabolism, neuromodulation, cardiovascular effect, infection, immunity, and tumorigenesis. The YTHDF family mediates tumor proliferation,

SUBMITTER: Chen L 

PROVIDER: S-EPMC10043241 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature