Time-of-day defines NAD⁺ efficacy to treat diet-induced metabolic disease by synchronizing the hepatic clock in mice.

ABSTRACT: The circadian clock is an endogenous time-tracking system that anticipates daily environmental changes. Misalignment of the clock can cause obesity, which is accompanied by reduced levels of the clock-controlled, rhythmic metabolite NAD⁺. Increasing NAD⁺ is becoming a therapy for metabolic dysfunction; however, the impact of daily NAD⁺ fluctuations remains unknown. Here, we demonstrate that time-of-day determines the efficacy of NAD⁺ treatment for diet-induced metabolic disease in mice. Increasing NAD⁺ prior to the active phase in obese male mice ameliorated metabolic markers including body weight, glucose and insulin tolerance, hepatic inflammation and nutrient sensing pathways. However, raising NAD⁺ immediately before the

SUBMITTER: Escalante-Covarrubias Q 

PROVIDER: S-EPMC10043291 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature