Myofibroblast Ccn3 is regulated by Yap and Wwtr1 and contributes to adverse cardiac outcomes.

ABSTRACT:

Introduction

While Yap and Wwtr1 regulate resident cardiac fibroblast to myofibroblast differentiation following cardiac injury, their role specifically in activated myofibroblasts remains unexplored.

Methods

We assessed the pathophysiological and cellular consequence of genetic depletion of Yap alone (Yap ^fl/fl ;Postn ^MCM ) or Yap and Wwtr1 (Yap ^fl/fl ;Wwtr1 ^fl/+ ;Postn ^MCM ) in adult mouse myofibroblasts following myocardial infarction and identify and validate novel downstream factors specifically in cardiac myofibroblasts that mediate pathological remodeling.

Results

Following myocardial infarction, depletion of Yap in myofibroblasts had min

SUBMITTER: Flinn MA 

PROVIDER: S-EPMC10043314 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature