Slowed gastrointestinal transit is associated with an altered caecal microbiota in an aged rat model.

ABSTRACT: Gastrointestinal (GI) motility is largely dependent upon activity within the enteric nervous system (ENS) and is an important part of the digestive process. Dysfunction of the ENS can impair GI motility as is seen in the case of constipation where gut transit time is prolonged. Animal models mimicking symptoms of constipation have been developed by way of pharmacological manipulations. Studies have reported an association between altered GI motility and gut microbial population. Little is known about the changes in gut microbiota profile resulting specifically from pharmacologically induced slowed GI motility in rats. Moreover, the relationship between gut microbiota and altered intestinal motility is based on studies using faecal samples, which are easier to obtain but do not accurately r

SUBMITTER: Parkar N 

PROVIDER: S-EPMC10043340 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature