Evaluation of limited-sampling strategies to calculate AUC_(0-24) and the role of CYP3A5 in Chilean pediatric kidney recipients using extended-release tacrolimus.

ABSTRACT: Background: Kidney transplantation (KTx) requires immunosuppressive drugs such as Tacrolimus (TAC) which is mainly metabolized by CYP3A5. TAC is routinely monitored by trough levels (C₀) although it has not shown to be a reliable marker. The area-under-curve (AUC) is a more realistic measure of drug exposure, but sampling is challenging in pediatric patients. Limited-sampling strategies (LSS) have been developed to estimate AUC. Herein, we aimed to determine AUC_(0-24) and CYP3A5 genotype in Chilean pediatric kidney recipients using extended-release TAC, to evaluate different LSS-AUC_(0-24) formulas and dose requirements. Patients and methods: We analyzed pediatric kidney recipients using different extended-release TAC brands to determine

SUBMITTER: Galvez C 

PROVIDER: S-EPMC10043346 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature