Epigenetic immune monitoring for COVID-19 disease course prognosis.

ABSTRACT:

Background

The course of COVID-19 is associated with severe dysbalance of the immune system, causing both leukocytosis and lymphopenia. Immune cell monitoring may be a powerful tool to prognosticate disease outcome. However, SARS-CoV-2 positive subjects are isolated upon initial diagnosis, thus barring standard immune monitoring using fresh blood. This dilemma may be solved by epigenetic immune cell counting.

Methods

In this study, we used epigenetic immune cell counting by qPCR as an alternative way of quantitative immune monitoring for venous blood, capillary blood dried on filter paper (dried blood spots, DBS) and nasopharyngeal swabs, potentially allowing a home-based monitoring approach.

Results

Epigenetic immune cell counting in venous blood showed equivalence w

SUBMITTER: Samans B 

PROVIDER: S-EPMC10043382 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature