Clinical updates on gliomas and implications of the 5th edition of the WHO classification of central nervous system tumors.

ABSTRACT:

Background

The 5th edition of the World Health Organization (WHO) classification of central nervous system tumors incorporated specific molecular alterations into the categorization of gliomas. The major revision of the classification scheme effectuates significant changes in the diagnosis and management of glioma. This study aimed to depict the clinical, molecular, and prognostic characteristics of glioma and its subtypes according to the current WHO classification.

Methods

Patients who underwent surgery for glioma at Peking Union Medical College Hospital during 11 years were re-examined for tumor genetic alterations using next-generation sequencing, polymerase chain reaction-based assay, and fluorescence in situ hybridization methods and enrolled in the analysis.

SUBMITTER: Guo X 

PROVIDER: S-EPMC10043404 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature