Genetic polymorphisms in CYP4F2 may be associated with lung cancer risk among females and no-smoking Chinese population.

ABSTRACT:

Background

Our study aimed to explore the potential association of CYP4F2 gene polymorphisms with lung cancer (LC) risk.

Methods

The five variants in CYP4F2 were genotyped using Agena MassARRAY in 507 cases and 505 controls. Genetic models and haplotypes based on logistic regression analysis were used to evaluate the potential association between CYP4F2 polymorphisms and LC susceptibility.

Results

This study observed that rs12459936 was linked to an increased risk of LC in no-smoking participants (allele: OR = 1.38, p = 0.035; homozygote: OR = 2.00, p = 0.035; additive: OR = 1.40, p = 0.034) and females (allele: OR = 1.64, p = 0.002; homozygote: OR = 2.57, p = 0.006; heterozygous: OR = 2.56, p = 0.001; dom

SUBMITTER: Shi H 

PROVIDER: S-EPMC10043406 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature