Effects of the circulating environment of COVID-19 on platelet and neutrophil behavior.

ABSTRACT:

Introduction

Thromboinflammatory complications are well described sequalae of Coronavirus Disease 2019 (COVID-19), and there is evidence of both hyperreactive platelet and inflammatory neutrophil biology that contributes to the thromoinflammatory milieu. It has been demonstrated in other thromboinflammatory diseases that the circulating environment may affect cellular behavior, but what role this environment exerts on platelets and neutrophils in COVID-19 remains unknown. We tested the hypotheses that 1) plasma from COVID-19 patients can induce a prothrombotic platelet functional phenotype, and 2) contents released from platelets (platelet releasate) from COVID-19 patients can induce a proinflammatory neutrophil phenotype.

Methods

We treated platelets with COVID-19 patient a

SUBMITTER: Fields AT 

PROVIDER: S-EPMC10043426 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature