Mixture effects of co-formulants and two plant protection products in a liver cell line.

ABSTRACT: Plant protection products (PPPs) consist of one or more active substances and several co-formulants. Active substances provide the functionality of the PPP and are consequently evaluated according to standard test methods set by legal data requirements before approval, whereas co-formulants' toxicity is not as comprehensively assessed. However, in some cases mixture effects of active substances and co-formulants might result in increased or different forms of toxicity. In a proof-of-concept study we hence built on previously published results of Zahn et al. (2018[38]) on the mixture toxicity of Priori Xtra^® and Adexar^® to specifically investigate the influence of co-formulants on the toxicity of these commonly used fungicides. Products, their respective active substan

SUBMITTER: Feiertag K 

PROVIDER: S-EPMC10043434 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature