Emerging of a new CD3⁺CD31^HCD184⁺ tang cell phenothype in Sjogren's syndrome induced by microencapsulated human umbilical cord matrix-derived multipotent stromal cells.

ABSTRACT:

Background

Sjögren's syndrome (SS) is an autoimmune disease hallmarked by infiltration and destruction of exocrine glands. Currently, there is no therapy that warrants full recovery of the affected tissues. Umbilical cord-derived multipotent stromal cells, microincapsulated in an endotoxin-free alginate gel (CpS-hUCMS), were shown to modulate the inflammatory activity of PBMCs in SS patients in vitro, through release of soluble factors (TGFβ1, IDO1, IL6, PGE2, VEGF). These observations led us to set up the present study, aimed at defining the in vitro effects of CpS-hUCMS on pro- and anti-inflammatory lymphocyte subsets involved in the pathogenesis of SS.

Methods and results

Peripheral blood mononuclear cells (PBMCs) upon collection from SS patients and matched

SUBMITTER: Montanucci P 

PROVIDER: S-EPMC10043489 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature