Effects of General Anesthesia Plus Multimodal Analgesia on Immediate Perioperative Outcomes of Hamstring Tendon Autograft ACL Reconstruction: A Randomized, Double-Blinded, Placebo-Controlled Trial.

ABSTRACT: Anterior cruciate ligament reconstruction with hamstring tendon autograft (H-ACLR) is a standard ambulatory procedure with the potential for considerable postoperative pain. We hypothesized that general anesthesia combined with a multimodal analgesia regimen would reduce postoperative opioid use associated with H-ACLR.

Methods

This study was a single-center, surgeon-stratified, double-blinded, placebo-controlled, randomized clinical trial. The primary end point was the total postoperative opioid use during the immediate postoperative period, and secondary outcomes included postoperative knee pain, adverse events, and ambulatory discharge efficiency.

Results

One hundred and twelve subjects, 18 to 52 years of age, were randomized to placebo (57 subjects) or combination multimod

SUBMITTER: Walczak BE 

PROVIDER: S-EPMC10043574 | biostudies-literature | 2023 Jan-Mar

REPOSITORIES: biostudies-literature