Photochemical Targeting of Mitochondria to Overcome Chemoresistance in Ovarian Cancer ^†.

ABSTRACT: Ovarian cancer is the most lethal gynecologic malignancy with a stubborn mortality rate of ~65%. The persistent failure of multiline chemotherapy, and significant tumor heterogeneity, has made it challenging to improve outcomes. A target of increasing interest is the mitochondrion because of its essential role in critical cellular functions, and the significance of metabolic adaptation in chemoresistance. This review describes mitochondrial processes, including metabolic reprogramming, mitochondrial transfer and mitochondrial dynamics in ovarian cancer progression and chemoresistance. The effect of malignant ascites, or excess peritoneal fluid, on mitochondrial function is discussed. The role of photodynamic therapy (PDT) in overcoming mitochondria-mediated resistance is presented. PDT, a

SUBMITTER: Rickard BP 

PROVIDER: S-EPMC10043796 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature