Associations between brain gene expression perturbations implicated by COVID-19 and psychiatric disorders.

ABSTRACT:

Background

Currently, there is increasing evidence from clinic, epidemiology, as well as neuroimaging, demonstrating neuropsychiatric abnormalities in COVID-19, however, whether there were associations between brain changes caused by COVID-19 and genetic susceptibility of psychiatric disorders was still unknown.

Methods

In this study, we performed a meta-analysis to investigate these associations by combing single-cell RNA sequencing datasets of brain tissues of COVID-19 and genome-wide association study summary statistics of psychiatric disorders.

Results

The analysis demonstrated that among ten psychiatric disorders, gene expression perturbations implicated by COVID-19 in excitatory neurons of choroid plexus were significantly associated with schizophrenia.

Concl

SUBMITTER: Gao Y 

PROVIDER: S-EPMC10043811 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature