Risk of cardiovascular events in patients having had acute calcium pyrophosphate crystal arthritis.

ABSTRACT:

Objectives

Calcium pyrophosphate deposition (CPPD) disease, broadly defined, has been associated with increased risk of cardiovascular (CV) events. We investigated risk of CV events in patients with acute CPP crystal arthritis, the acute manifestation of CPPD.

Methods

Cohort study using Mass General Brigham electronic health record (EHR) data, 1991-2017. Patients with acute CPP crystal arthritis were identified using a published machine learning algorithm with positive predictive value 81%. Comparators were matched on year of EHR entry and index date of patients with acute CPP crystal arthritis (first positive synovial fluid CPP result or mention of 'pseudogout', or matched encounter). Major adverse cardiovascular event (MACE) was a composite of non-fatal CV event (myocardia

SUBMITTER: Tedeschi SK 

PROVIDER: S-EPMC10043830 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature