Rapid deracemization through solvent cycling: proof-of-concept using a racemizable conglomerate clopidogrel precursor.

ABSTRACT: We demonstrate that a conglomerate-forming clopidogrel precursor undergoing solution phase racemization can be deracemized through cyclic solvent removal and re-addition. We establish that the combination of slow growth and fast dissolution of crystals is ideal for rapid deracemization, which we achieve by repurposing a Soxhlet apparatus to realize the slow removal and fast re-addition of solvent autonomously.

SUBMITTER: van Dongen SW 

PROVIDER: S-EPMC10043878 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature