Altered intestinal microbiome and metabolome correspond to the clinical outcome of sepsis.

ABSTRACT:

Background

The gut microbiome plays a pivotal role in the progression of sepsis. However, the specific mechanism of gut microbiota and its metabolites involved in the process of sepsis remains elusive, which limits its translational application.

Method

In this study, we used a combination of the microbiome and untargeted metabolomics to analyze stool samples from patients with sepsis enrolled at admission, then microbiota, metabolites, and potential signaling pathways that might play important roles in disease outcome were screened out. Finally, the above results were validated by the microbiome and transcriptomics analysis in an animal model of sepsis.

Results

Patients with sepsis showed destruction of symbiotic flora and elevated abundance of Enterococcus, which wer

SUBMITTER: Sun S 

PROVIDER: S-EPMC10044080 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature